Generic Name | Trade Names | Pregnancy Category | Pregnancy Notes | Lactation Notes |
Acetaminophen | Tylenol™ | B | Compatible | Compatible |
Ibuprofen | Advil | B | 1st and 3rd trimester risk | Compatible |
Codeine | in Robitussin AC™ and Tylenol #3 | C | 3rd trimester risk | Limited human data, probably compatible |
Hydroxyzine | Vistaril | C | Human data suggest low risk | |
Pyridoxine, Vitamin B6 | | A | Compatible | Compatible, but excessively high doses inhibit lactation |
Metoclopramide | Reglan | B | Compatible | Unknown effects, limited human data, potential toxicity due to dopaminergic blocking mechanism. However, sometimes given to induce lactation. |
Promethazine | Phenergan | C | Compatible | No human data, probably compatible |
Ondansetron | Zofran | B | Limited human data, animal data suggest low risk. | No human data, probably compatible |
Doxylamine | | A | Compatible | No human data, probably compatible |
Trimethobenzamide | Tigan | C | Human data suggest low risk | No human data, probably compatible |
Saline Nasal spray | Ocean™ | A | Safe | Safe |
| Vick's vapor-rub | | Not ingested, and therefore safe | Safe |
Steam inhalation | | | Safe | Safe |
Vaseline | | | applied nasally or on lips, and therefore safe | Safe |
| NasalCrom™ | B | Compatible | No data, probably compatible |
| Afrin™ | C | insufficient evidence. Small studies show normal use ok, but heavy use, (against label), results in fetal brady most likely from vasoconstrictor activity. | Compatible |
| Flonase™ | C | No other data found by me | Unknown, no other data found by me |
| Nasocort™ | C | No other data found by me regarding nasal administration, but other routes are classified as having risk. | No human data, probably compatible |
Dextromethorphan | in Robitussin DM | C | Compatible | Compatible |
Codeine | | See above | | |
Diphenhydramine | Benadryl | B | Compatible | Limited human data, probably compatible, though antihistamines are suspected to decrease lactation |
Loratadine | Claritin™ | B | | |
Cetirizine | Zyrtec™ | B | | |
Pseudoephedrine | Sudafed™ | C | Limited human data and no relevant animal data, not recommended before 18weeks given association with omphalocele | Limited human data, probably compatible, compatible per AAP, but known to sometimes reduce or halt lactation |
Phenylephrine | | C | Human data suggest risk | No human data, probably compatible, but known to sometimes reduce or halt lactation |
Guaifenesin | in Robitussin DM, AC, and Mucinex™ | C | Compatible, Surveillance studies show no increased risks of birth defects | No human data, probably compatible |
Ranitidine | Zantac | B | Compatible | Limited human data, probably compatible, cimetidine compatible per AAP |
Pantoprazole | Protonix | B | No human data, animal data suggest low risk | Limited human data with potential toxicity |
Omeprazole | Prilosec | C | Human data suggest low risk | Limited human data with potential toxicity |
Fluconazole | Diflucan | C | Human data suggest risk at >=400mg/day 1st trimester especially | Compatible |
Cephalexin | Keflex | B | Safe | Safe |
Ciprofloxacin | | C | Human data suggest risk | Limited human data, probably compatible, compatible per AAP |
Nitrofurantoin | Macrobid | B | Risk in 3rd trimester of hemolytic anemia possibly from immature erythrocyte enzymes - glutathione. | Limited human data, probably compatible |
TMP-SMX | Bactrim, Septra | C | Human data suggest risk | Compatible |
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